Companies In San Diego — Key Highlights
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Qualcomm generated $38.96 billion in revenue in 2024, making it the top-earning company headquartered in San Diego.
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With a market cap of around $162 billion, Qualcomm stands as San Diego’s most valuable publicly traded company.
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Sempra reported $13.18 billion in revenue in 2024, positioning it as the second-highest revenue-generating company in San Diego.
San Diego isn’t just about sunshine and surf — it’s also an economic engine driving innovation across tech, biotech, finance and real estate.
As of 2025, its labor force includes over 1.67 million people, supporting a diverse mix of industries and fueling one of the most productive regional economies in California.
In this report, we break down the top-performing companies headquartered in San Diego, with revenue, market cap and employment stats that reflect the city’s growing global reach.
Tech Companies In San Diego
With a steady flow of venture capital, strong university pipelines and access to cross-border talent, San Diego has quietly built one of the most dynamic tech scenes on the West Coast.
As a leader in mobile chipsets and wireless technology, Qualcomm has been instrumental in shaping the city’s reputation as a center for innovation.
Today, the city’s tech economy is powered by a mix of established companies and emerging startups, all contributing to a fast-growing and increasingly competitive sector.
Here’s a look at how Qualcomm and other San Diego tech companies have been performing in recently:
- Qualcomm reported a revenue of $38.96 billion in 2024.
- In 2024, Qualcomm generated approximately $9.5 billion in revenue from the U.S., while revenue from China was notably higher, reaching just under $18 billion.
- In 2024, Qualcomm generated $32.79 billion in revenue from equipment and services.
- Qualcomm’s net income in 2024 was $10.14 billion.
- As of late May 2025, Qualcomm has a market cap of around $162 billion.
- Around 49,000 people are employed by Qualcomm.
- Teradata reported a revenue of $1.75 billion in 2024.
- Teradata’s net income in 2024 was $114 million.
- As of late May 2025, Teradata has a market cap of around $2 billion.
- Around 5,700 people are employed by Teradata.
- Mitek Systems reported a revenue of $172.08 million in 2024.
- Mitek Systems’ net income in 2024 was $3.27 million.
- As of late May 2025, Mitek Systems has a market cap of around $370 million.
- Around 630 people are employed by Mitek Systems.
Why These Numbers Matter
- Qualcomm is San Diego’s biggest company by revenue and market cap. With nearly $39 billion in annual revenue and a valuation of $162 billion, Qualcomm’s global footprint cements San Diego’s role as a major force in the tech world.
- San Diego is climbing the national tech ranks. In CBRE’s 2024 Scoring Tech Talent report, San Diego jumped five spots to rank 17th among North America’s top 25 tech hubs, making it one of the fastest-rising markets in the region.
- Big Tech is gaining ground in San Diego. In 2024, the city saw a 7% rise in Big Tech roles, while startups experienced a 3.5% drop in workforce, indicating that talent is shifting toward more established companies with greater resources and stability.
Healthcare and Biotech Companies In San Diego
San Diego is home to some of the most innovative healthcare companies in the world, spanning biotech, medical devices and life sciences.
The city’s strong research infrastructure, top-tier universities and skilled talent pool have made it a magnet for healthcare giants and growing firms alike.
From developing cutting-edge diagnostics to manufacturing life-saving therapies, these companies play a vital role in both the local economy and the advancement of global healthcare.
Here’s a look at some of the most prominent healthcare companies based in San Diego and how they’ve been performing recently:
- Resmed reported $4.68 billion in revenue for the 12-month period ending June 2024.
- For the same period, Resmed reported a net income of $1.02 billion.
- As of late May 2025, Resmed has a market cap of around $36 billion.
- Around 10,000 people are employed by Resmed.
- Dexcom reported a revenue of $4.03 billion in 2024.
- Dexcom’s net income in 2024 was $576.2 million.
- As of late May 2025, Dexcom has a market cap of around $34 billion.
- Dexcom’s customer base grew to between 2.8 and 2.9 million users globally.
- Around 10,300 people are employed by Dexcom.
- Illumina reported a revenue of $4.37 billion in 2024.
- In 2024, Illumina reported a loss of $1.22 billion.
- As of late May 2025, Illumina has a market cap of around $13.5 billion.
- Illumina has a total active installed base of around 22,000.
- Around 9,000 people are employed by Illumina.
- Neurocrine Biosciences reported a revenue of $2.35 billion in 2024.
- Neurocrine Biosciences’ net income in 2024 was $341.3 million.
- As of late May 2025, Neurocrine Biosciences has a market cap of around $12 billion.
- Around 1,800 people are employed by Neurocrine Biosciences.
- Halozyme Therapeutics reported a revenue of $1.01 billion in 2024.
- Halozyme Therapeutics’ net income in 2024 was $444 million.
- As of late May 2025, Halozyme Therapeutics has a market cap of around $6.7 billion.
- Around 350 people are employed by Halozyme Therapeutics.
Why These Numbers Matter
- Healthcare is a major economic driver in San Diego. In addition to the companies mentioned above, the region is home to other publicly traded healthcare firms like ACADIA Pharmaceuticals, Avidity Biosciences and Viking Therapeutics, making it one of the strongest life sciences clusters in the U.S.
- Billions in revenue and market value highlight San Diego’s global influence. These companies are not just local success stories — they’re international players shaping the future of diagnostics, medical devices and biopharma.
- Thousands of high-paying jobs fuel the local workforce. With companies like Dexcom and ResMed each employing over 10,000 people, the healthcare sector plays a critical role in supporting skilled employment and talent retention in the region.
Real Estate Companies In San Diego
San Diego’s real estate sector isn’t just about beachfront homes and high-rise condos — it’s also a hub for large-scale commercial property investment.
The city is home to several real estate investment trusts (REITs) that manage billions in assets across the country, including retail centers, office buildings and mixed-use developments.
These firms offer investors consistent returns and contribute significantly to the region’s financial stability.
Their performance provides valuable insight into the broader health of both the local and national real estate markets:
- Real estate investment trust Realty Income reported revenue of $5.27 billion in 2024.
- Realty Income’s net income in 2024 was $199.6 million.
- As of late May 2025, Realty Income’s market cap is around $50 billion.
- Realty Income’s portfolio consists of approximately 15,600 commercial properties.
- Around 470 people are employed by Realty Income.
- Real estate investment trust American Assets Trust reported a revenue of $0.45 billion in 2024.
- American Assets Trust’s net income in 2024 was $57 million.
- As of late May 2025, American Assets Trust’s market cap is around $1.5 billion.
- Around 230 people are employed by American Assets Trust.
Why These Numbers Matter
- San Diego is home to major publicly traded REITs. Realty Income and American Assets Trust are two nationally recognized REITs headquartered in the city, collectively managing thousands of commercial properties and billions in real estate assets.
- REITs provide consistent income and long-term stability. Despite economic shifts, these companies continue to generate steady revenue, offering dependable returns for investors and contributing to the city’s financial ecosystem.
- San Diego’s commercial real estate market shows resilience amid national challenges. While many U.S. cities face declining office property values, San Diego has experienced growth in this sector since 2022. This resilience is attributed to the city’s diverse tenant base and proactive strategies, such as converting underutilized office spaces for alternative uses, helping to maintain property values.
Finance Companies In San Diego
San Diego is home to a diverse and growing financial sector that spans wealth management, lending, asset recovery and more.
The city’s finance companies range from large national operations to specialized firms, contributing significantly to both the local economy and the broader financial system.
With billions in annual revenue and thousands of jobs supported, finance remains a key part of San Diego’s economic strength.
Recent figures highlight just how substantial their economic footprint has become:
- LPL Financial Holdings revenue for 2024 was $12.38 billion.
- LPL Financial Holdings’ net income in 2024 was $1.05 billion.
- As of late May 2025, LPL Financial Holdings has a market cap of around $30.5 billion.
- Around 9,000 people are employed by LPL Financial Holdings.
- Guild Holdings reported a revenue of $1.04 billion in 2024.
- Guild Holdings’ net income in 2024 was $97.1 million.
- As of late May 2025, Guild Holdings has a market cap of around $880 million.
- Over 4,200 people are employed by Guild Holdings.
- Encore Capital Group reported a revenue of $1.31 billion in 2024.
- Encore Capital Group reported a loss of $139.24 million in 2024.
- As of late May 2025, Encore Capital Group has a market cap of around $880 million.
- Around 7,300 people are employed by Encore Capital Group.
Why These Numbers Matter
- San Diego plays a national role in finance. With billions in revenue and high market valuations, the city’s financial firms reach and influence well beyond Southern California.
- Diverse business models offer resilience. From mortgage lending to investment platforms and debt recovery, the variety of financial services based in San Diego helps reduce industry volatility.
- The city has global recognition. According to the Global Financial Centres Index, San Diego holds the 36th position globally, reflecting its growing influence in the financial sector.
Companies In Other Industries In San Diego
San Diego’s economy isn’t driven by just one industry — it thrives on a mix of sectors that go beyond its well-known strengths in tech and biotech.
Some of the top companies in San Diego are leaders in energy, retail and manufacturing, with operations that span the globe and revenues in the billions.
Their presence strengthens the region’s economic base and supports thousands of jobs across different skill levels.
Here’s how a few of these companies have been performing lately:
- Utility holding company Sempra reported a revenue of $13.18 billion in 2024.
- Sempra’s net income in 2024 was $1.60 billion.
- As of late May 2025, Sempra has a market cap of around $50 billion.
- Over 20,000 people are employed by Sempra.
- Membership warehouse clubs operator Pricesmart reported a revenue of $4.91 billion for the 12-month period ending August 2024.
- Pricesmart’s net income for the same period was $138.87 million.
- As of late May 2025, Pricesmart has a market cap of around $4.7 billion.
- Around 12,000 people are employed by Pricesmart.
- Penetrating oil manufacturer WD-40 reported a revenue of $590.55 million.
- WD-40’s net income in 2024 was $69.6 million.
- As of late May 2025, WD-40 has a market cap of around $3.2 billion.
- WD-40 sold $558,036 maintenance products in 2024.
- Around 650 people are employed by WD-40.
Why These Numbers Matter
- San Diego’s economy benefits from cross-sector strength. The presence of billion-dollar firms in energy, retail and consumer goods helps insulate the city’s economy from single-industry downturns.
- Global-facing companies raise the city’s profile. With international operations and supply chains, these businesses connect San Diego to key markets across the Americas and beyond.
- Manufacturing drives a $47 billion annual economic impact. San Diego’s manufacturing sector encompasses over 4,400 establishments and supports more than 121,000 jobs, accounting for nearly one in ten private sector positions in the region.
Grow Your San Diego Business With Digital Silk
Companies in San Diego continue to drive innovation and growth across a wide range of sectors, including tech, healthcare, real estate, finance and manufacturing.
Their scale and diversity are key reasons why the region remains one of the most economically resilient metro areas in California.
From billion-dollar public firms to specialized players in high-demand niches, these companies support tens of thousands of jobs and contribute to the city’s growing national and global influence.
In a market as active and fast-moving as San Diego, having a strong digital presence is key to staying visible and competitive.
At Digital Silk, we’re a full-service digital marketing agency in San Diego, committed to helping local businesses grow, engage audiences and outpace the competition. Our custom digital strategies are designed to elevate your brand and deliver measurable results.
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Contact us online, call (800) 206-9413 or use the Request a Quote form below to schedule your free consultation.
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